星空无限传媒

Education

Ph.D., Korea University, 1999

MS, Korea University, 1991

BS, Korea University, 1989

Research Interest

I am interested in viral research on RSV and influenza (human, swine, and avian) universal vaccine development, targeting metastable viral fusion glycoproteins using virus-like particle (VLP) platforms and viral vectored vaccines generated through reverse genetics. My viral research focuses on viral vaccine development and host鈥搗irus interactions, with an emphasis on vaccine evaluation in small animal models, and on viral antigen epitope design to screen therapeutic monoclonal antibodies for viral infectious diseases, including Varicella zoster virus, JC virus, and norovirus, utilizing phage display technologies.

More recently, my work has expanded to the development of Bovine herpesvirus type 1 (BHV-1) virus vectored and pseudorabies virus vectored vaccines presenting multiple antigens for the prevention of viral infectious diseases in cattle.

Patents

Respiratory syncytial virus (rsv) vaccines; US20210052718A1

Publications

Young-Man Kwon, Hye Suk Hwang, Ki-Hye Kim, Young-Tae Lee, Eun-Ju Ko, Arun Meas, Sang-Moo Kang,鈥� Virus-like Particle Vaccines Containing RSV Fusion Protein Cleavage Mutations Are Immunogenic and Protective in Cotton Rats With a Prime Dose鈥�, Immune Network, 2025, 25(5), e37.

Park, Bo Ryoung, Subbiah, Jeeva, Kim, Ki-Hye, Kwon, Young-Man, Oh, Judy, Kim, Min-Chul, Shin, ChongHyun, Seong, Baik Lin, Kang, Sang-Moo, 鈥淓nhanced cross protection by hetero prime-boost vaccination with recombinant influenza viruses containing chimeric hemagglutinin-M2e epitopes鈥�, Virology, 2022, 566, 143-152.

Park, Bo Ryoung, Kim, Ki-Hye, Kotomina, Tatiana, Kim, Min-Chul, Kwon, Young-Man, Jeeva, Subbiah, Jung,Yu-Jin, Bhatnagar, Noopur, Isakova-Sivak, Irina, Mezhenskaya, Daria, Rudenko, Larisa, Wang, Bao-Zhong, Kang, Sang-Moo, 鈥淏road cross protection by recombinant live attenuated influenza H3N2 seasonal virus expressing conserved M2 extracellular domain in a chimeric hemagglutinin鈥�, Scientific Reports, 2021, 11(1), 4151.

Kwon, Young-Man, Lee, Youri, Kim, Ki Hye, Jung, Yu Jin, Li, Zhuo, Jeeva, Subbiah, Lee, Sujin, Moore, Martin L, Kang, Sang-Moo, 鈥淎ntigenicity and immunogenicity of unique prefusion-mimic F proteins presented on enveloped virus-like particles鈥�, Vaccines(Basel), 2019, 37(44), 6656-6664

Kwon, Young-Man, Hwang, Hye Suk, Lee, Young-Tae, Kim, Ki-Hye, Lee, Youri, Kim, Min-Chul, Lee, Yu-Na,Quan, Fu-Shi, Moore, Martin L, Kang, Sang-Moo, 鈥淩espiratory Syncytial Virus Fusion Protein-encoding DNA Vaccine Is Less Effective in Conferring Protection against Inflammatory Disease than a Virus-like Particle Platform鈥�, Immune Netw., 2019, 19(3), e18.

Kim, Yu-Jin, Kim, Ki-Hye, Ko, Eun-Ju, Kim, Min-Chul, Lee, Yu-Na, Jung, Yu-Jin, Lee, Young-Tae, Kwon,Young-Man, Song, Jae-Min, Kang, Sang-Moo, 鈥淐omplement C3 Plays a Key Role in Inducing Humoral and Cellular Immune Responses to Influenza Virus Strain-Specific Hemagglutinin-Based or Cross-Protective M2 Extracellular Domain-Based Vaccination鈥�, J Virol., 2018, 92(20).

Lee, Young-Tae, Kim, Ki-Hye, Hwang, Hye Suk, Lee, Youri, Kwon, Young-Man, Ko, Eun-Ju, Jung, Yu-Jin,Lee, Yu-Na, Kim, Min-Chul, Kang, Sang-Moo, 鈥淚nnate and adaptive cellular phenotypes contributing to pulmonary disease in mice after respiratory syncytial virus immunization and infection鈥�, Virology, 2015, 485, 36-46.

Lee, Yu-Na, Hwang, Hye Suk, Kim, Min-Chul, Lee, Young-Tae, Cho, Min-Kyoung, Kwon, Young-Man, Lee,Jong Seok, Plemper, Richard K, Kang, Sang-Moo, 鈥淩ecombinant influenza virus carrying the conserved domain of respiratory syncytial virus (RSV) G protein confers protection against RSV without inflammatory disease鈥�,Virology, 2015, 476, 217-225.

Kwon, Young-Man, Lee Jong Seok, Hwang, Hye Suk, Lee, Yu-Na, Ko, Eun-Ju, Yoo, Si-Eun, Kim, Min-Chul,Kim, Ki-Hye, Cho, Min Kyoung, Lee, Young-Tae, Lee, You Ri, Quan, Fu-Shi, Kang, Sang-Moo, 鈥淏aculovirus expressed virus-like particle vaccine in combination with DNA encoding the fusion protein confers protection against respiratory syncytial virus鈥�, Vaccine, 2014, 32(44), 5866-5874.

Kwon, Young-Man, Hwang, Hye Suk. Lee, Jong Seok. Ko, Eun-Ju. Yoo, Si-Eun. Kim, Min-Chul. Lee, Yu-Na.Kim, Ki-Hye. Song, Jae-Min. Lee, Sujin. Moore, Martin L. Kang, Sang-Moo. 鈥淢aternal antibodies by passive immunization with formalin inactivated respiratory syncytial virus confer protection without vaccine-enhanced disease鈥�, Antiviral Res., 2014, 104, 1-6.